mit biophysical instrumentation facility

The laboratory has various in-house facilities for the design, fabrication, integration, and test of flight hardware. Accessibility Statement, COVID-19 and Research Ramp Up Information for the MIT Research Community, Financial Conflicts of Interest in Research, COVID-19 Related Information for the MIT Research Community, Establishing and Managing a Service Center, ES Cell & Transgenic Animal Core Facility, The Hope Babette Tang (1893) Histology Facility, Department of Chemistry Instrumentation Facility, Laboratory Instruments and Electronics Service, Materials Analysis SEF (Surface, Thermal, and Optical), Peterson (1957) Nanotechnology Materials Core Facility, The Barbara K. Ostrom (1978) Bioinformatics & Computing Facility, Microsystems Technology Laboratories Facilities, Scanning Electron Beam Lithography (SEBL) Facility, Animal Imaging & Preclinical Testing Core Facility, Laboratory for Physical Metallurgy (Metlab), Materials Research Laboratory X-ray Diffraction Shared Experimental Facility. This common facility will integrate the various research goals of members of the Picower and McGovern Institutes, and the Department of Brain and Cognitive Sciences. The X-Ray Diffraction SEF contains a suite of X-ray instruments for analysis of polycrystalline samples, coatings, epitaxial thin films, nanostructured samples, polymers, and single crystals. The Microsystems Technology Laboratories microfabrication facilities include three cleanroom labs, which offer varying degrees of flexibility and cleanliness levels: Integrated Circuits Laboratory (ICL) -CMOS-compatible processes; Technology Research Laboratory (TRL)- CMOS-compatible plus opto-electronics, MEMS and other semiconductor processes; Exploratory Materials Laboratory (EML) - flexible processes on many materials; and Electron-beam Lithography facility (EBL) - enables writing patterns of arbitrary geometries with minimum features sizes as fine as 5 nm. The MIT X-ray diffraction facility offers single crystal X-ray data collection, structure solution and refinement of small molecule structures (< 350 non-hydrogen Atoms). This course covers sensing and measurement for quantitative molecular/cell/tissue analysis, in terms of genetic, biochemical, and biophysical properties. From working with researchers to develop data management plans, through advising on how to conduct effective data management during research execution, to providing recommendations on final data sharing and publication, as frequently required by funders and journals, DMS partners to increase the impact and effectiveness of data. The Space Propulsion Laboratory (SPL) houses experimental facilities to support research and educational programs for MIT students. Analytical services are available for the faculty and professionals. The instruments in the facility form part of the Center for Geochemical Analysis (CGA), which comprises six instrument-oriented facilities. Also provides access to instrumentation for in vivo, whole animal imaging, including bioluminescence, fluorescence, ultrasound, and microCT tecnologies. W elcome to the Y ale CBIC The Yale Chemical and Biophysical Instrumentation Center (CBIC) is an extensive collection of analytical instruments for scientific research supervised by a professional staff. A state-of-the-art laboratory in the Department of Materials Science and Engineering at MIT for probing the properties and surfaces of engineering and biological materials at atomic and molecular length scales through mechanical contact. Core facilities generally recover their cost, or a portion of their cost, in the form of user fees that are charged to an investigator's grant, contract or, in some cases, discretionary funds. Biophysical Instrumentation Facility. The Structural Biology Core Facility is open to the entire MIT community in structural biology and provides access to state-of-the-art equipment for X-ray crystallography. Currently investigating a number of interesting research areas, including advanced drug delivery techniques and high temperature superconductivity. It is largely used by researchers in Chemistry, Biology and BioEngineering but is available to anyone on campus and beyond. The microprobe facility serves a broad spectrum of research scientists at MIT, Woods Hole Oceanographic Institution (WHOI), neighboring universities, academic institutions and the industry. The Laboratory for Advanced Materials (LAM) is in 8-102. Services include light and epifluorescence microscopy, deconvolution-based microscopy, spinning disk confocal microscopy, total internal reflection fluorescence microscopy, spectral karyotyping and fluorescent in situ hybridization, laser capture microdissection, and standard transmission electron and immunoelectron microscopy. Upcoming Seminars: A significant fraction of SPL's research is focused on the development and modeling of space thrusters. Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research) Visit the Capital Projects site for project updates as we continue shaping the future of … Experiments with conventional and novel propulsion devices, drag reduction using MHD (magneto-hydrodynamics), flow control by unsteady swimming motion and flapping foils, offshore cylinder testing and vortex-induced-vibrations are performed using state of the art measurement techniques and instrumentation. This shared resource of the Koch Institute provides fee-for-service support to all MIT investigators who utilize cultured ES cells or novel mouse models to study human diseases such as cancer. The main facility is a variable pressure recirculating water tunnel that is capable of speeds up to 10 m/s. RIKEN Brain Science Institute. Biophysical Instrumentation Facility (BIF) The BIF houses instrumentation for aiding in the elucidation of macromolecular structure and interaction. To gain access, please fill out the online Outreach form. This includes the determination of the absolute configuration of chiral molecules from anomalous scattering. This technology allows simultaneous multiparametric analysis of many thousands of cells per second, enabling trained researchers to rapidly analyze complex cell populations using benchtop analysis flow cytometers. Provides state of the art instrumentation and technical expertise to generate and interpret microscopic images; assists investigators in applying sophisticated microscopy techniques to their research; and trains researchers in microscopy techniques and methodology. This facility houses instruments to elucidate macromolecular structure, including an analytical ultracentrifuge, a CD spectrometer, a dynamic light scatterer, a differential scanning calorimeter, an isothermal titration calorimeter, a capillary electrophoresis instrument and a bio-layer interferometer. “It’s because we have these tools we’ve built up at MIT over the years.” They also synthesized a shorter sequence of only 12 amino acids found in the alpha helix, and then tested both of the peptides using equipment at MIT’s Biophysical Instrumentation Facility that can measure how strongly two molecules bind together. Click here for our maps. Transmission Electron Microscopy (TEM) allows the researcher to form images of thin slices or nano particles of samples at a resolution of down to 0.14 nm (lattice resolution). It is a resource specific to members of the Department of Chemistry. The Biophysics Instrumentation Facility (BIF) is part of the Department of Biochemistry at the University of Wisconsin-Madison and is located in Room 4420 of the Biochemical Sciences Building. The facility is largely used by researchers in chemistry, biology, and biological engineering, but is available to anyone on campus and beyond. The various BCS, McGovern, and Picower laboratories have expertise and experience with dfferent experimental protocols which, when combined in a collective manner to the study of human cells, will result in accelerated progress in this novel, dynamic and competitive field. The Scanning Electron Microscope (SEM) is a tool for visualizing the surface of solid samples, with a resolution (depending on the application) that can approach 1nm. Research at the GTL is focused on advanced propulsion systems and turbomachinery with activities in computational, theoretical, and experimental study of: (1) loss mechanisms and unsteady flows in turbomachines, (2) compression system stability and active control, (3) heat transfer in turbine blading, (4) gas turbine engine noise reduction and aero-acoustics, (5) pollutant emissions and community noise, and (6) MEMS-based high-power-density engines. To capitalize on this opportunity, the Army decided to create the Institute for Soldier Nanotechnologies as a university center for basic research on nanotechnology. NRL staff also provide technical assistance for research projects for high school students, undergraduate and graduate students, university researchers and faculty members, and national laboratory users. Project Overview. Many of these facilities are available on a fee-for-service basis to all investigators. The Peterson (1957) Nanotechnology Materials Core Facility provides a broad range of equipment and expertise to work with nanomaterials for the purposes of both characterization and imaging. The MIT Kavli Institute (MKI) for Astrophysics and Space Research is one of the world’s leading institutions for research in astrophysics. Reopening Polices and Covid-19 Updates If you have trouble accessing this page and need to request an alternate format, contact u@osu.edu Instrumentation for material characterization includes high throughput particle sizing, HPLC and dedicated nucleic acid HPLC, dynamic mechanical analysis, and rheometry. The Department of Chemistry Instrumentation Facility is the shared instrument facility for the Chemistry Department located in the sub-basement of the Camille Edouard Dreyfus Building on the main MIT campus. 20.409 Biological Engineering II: Instrumentation and Measurement. Majority of services rendered pertain to massively parallel sequencing using the Illumina platform, commercial array processing, real-time PCR, and informatics and computational support. The Laboratory for Physical Metallurgy (or Metlab for short) is a shared facility in the Department of Materials Science and Engineering. ADDRC Equipment. The facility is under the management of Giovanni Gonzalez-Gutierrez. Computational & Systems Biology PhD Program (CSB) 77 Massachusetts Avenue Bldg 68, Room 230A Cambridge, MA 02139. csbphd@mit.edu 617.324.4144. Biophysics Instrumentation Core Facility The Biophysics Instrumentation Core (BIC) Facility offers sophisticated instrumentation dedicated to characterizing biomolecular conformations and interactions, as well as equipment for the isolation and purification of macromolecules for subsequent detailed biophysical analysis. The High Throughput Screening Facility provides automated screening capability to KI and MIT researchers, as well as access to curated small molecule and lentiviral shRNA (RNAi) libraries. It is staffed 40 hours a week by Debby Pheasant who is available to train new users and provide advice to anyone considering potential applications of the equipment in the facility. Office of the Vice President of the Research, 77 Massachusetts Avenue, Bldg NE 18-901 76-181 (Biopolymers); 76-387 (Proteomics). The facility is equipped with an Arrayscan automated confocal high content screening microscope, Tecan Evo liquid handlers, plate washers, automated micoplate centrifuges, an automated plate reader, and automated CO2 incubators. The Department of Chemistry Instrumentation Facility is the shared instrument facility for the Chemistry Department located in the sub-basement of the Camille Edouard Dreyfus Building on the main MIT campus. It is a shared facility, designed for flexible use. Data Management Services (DMS) provides the MIT research community with expertise on managing research data throughout the research data life-cycle. Coronavirus update: COVID-19 and Research Ramp Up Information for the MIT Research Community. Biophysical Instrumentation Core Facility The CSB maintains a variety of instruments for studying the conformation and stability of macromolecules and for measuring the affinity and thermodynamics of biomolecular interactions. MKI combines forty years of expertise in space- and ground-based instrumentation development with the intellectual energy of MIT’s faculty, research and technical staff, and students. We are located in the Chemistry Research Building rm 100 and Kline Chemistry Laboratory rms 3, 6, 7 and 8. Energy-dispersive X-ray analysis can be used to analyze volumes with dimensions of around 1 micron with a sensitivity of about 0.2wt%, while back-scattered electron imaging allows the visualization of regions of different composition. Please send additions or updates to this listing to the VPR webmaster. Biophysical Instrumentation Facility (Study of Complex Macromolecular Systems (NSF-0070319)) en_US: dc.description.sponsorship: Massachusetts Institute of Technology. The smaller visualization tank, consisting of a three axis motor system, and outfitted with a high-speed particle image velocimetry (PIV) system, is used primarily for the quantitative visualization of fluid flows. SMART CAMP (Critical Analytics for Manufacturing Personalized-Medicine) is a new interdisciplinary research programme in Singapore (CREATE international research campus and innovation hub) and at the Massachusetts Institute of Technology (MIT).SMART CAMP addresses key technology bottlenecks in cell therapy manufacturing: (i) critical quality attributes of … Sensing and measurement aimed at quantitative molecular/cell/tissue analysis in terms of genetic, biochemical, and biophysical properties. Massachusetts Institute of Technology. The LEM includes a variety of prototyping and machining equipment available to DMSE  for fabrication of experimental equipment, sample preparation, and general machining needs. The facility can meet a wide range of needs, from one-off experiments of limited scope, to long-term maintenance of dozens of transgenic and/or mutant lines. Services encompass embryonic stem cells, microinjections, repositories of reagent mice, and much more. DMS offers individual consultations, general workshops, and customized workshops on issues of data management. Provides services for members of the MIT community and outside users. It is a resource specific to members of the Department of Chemistry. The Harvard Catalyst Clinical Research Center at MIT (, Imaging: Animal Modeling and Clinical Testing. Across the Institute, there are more than 50 core facilities. Cambridge, MA 02139, Contact the VPR Webmaster Applied Biosystems 7900HT 384-well plate qPCR Facility; Biacore (Surface Plasmon Resonance) Facility; Cressington Quick Freeze-Deep Etch EM Prep Facility; Multiphoton Microscopy Facility; Alpha Innotech Gel Imaging Facility. Similarly, requests for training on any specific instrument must be initiated via the training page. In this role, Dr. Gonzalez-Gutierrez can handle all your biophysical characterization needs from training to data interpretation. Services include routine Sanger DNA sequencing, mass spectrometry-based proteomics approaches for identification, characterization, or quantitation of proteins, MALDI-TOF mass spectrometry, peptide synthesis and purification, and high-pressure liquid chromatographic analysis and purification. Biophysical Instrumentation Facility (Study of Complex Macromolecular Systems (NIH GM68762 instrumentation grant) en_US: dc.publisher Requests for shop services can be done either in person or from the Central Machine Shop webpage. An hourly fee is charged. In some circumstances, access may be available to non-member MIT users. Meg Rheault - Administrative Assistant. The assortment of equipment has been selected to provide flexibility so that we can accommodate a wide variety of demanding research. The instruments can be used in either walk-up or automated modes using our robot arms for general screening or plate preparation. And interaction UV-visible-near IR spectrophotometry, Fourier transform infrared spectroscopy, Raman spectroscopy future of Academic! Massachusetts Institute of Technology but is available to non-member MIT users of flight hardware (, imaging: Animal and..., HRXRD, SAXS, XRF and Laue diffraction Cryo-EM Center is located in MIT.nano a... 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